prologue
All Good Things — the opening.
Withering Away — Esme's medicine, and the prologue's one hard failure.
Like Father, Like Son — training with Pieter, and the Charge Manual.
Sacred Covenant — the Blood Mass.
Bad Blood — the aftermath.
Smoke and Ashes — the return to Laslea, which opens the valley.
Every prologue side quest disappears when the prologue ends. Nothing in the following thirty days brings them back.
The chain of six main quests above is reported by a retail walkthrough; that the prologue is a fixed linear opening is official. No time cost is published for the prologue as a whole — plan it as setup, not as part of your route.